Effect of Topiramate on Mitochondrial Biogenesis and Neuroinflammation in Chronic Constriction Injury and Streptozotocin-induced Peripheral Neuropathy

Abstract: Background: Because neuropathic pain is currently a poorly understood medical condition, there need to identify more effective therapeutic drug with low toxicity profile. Purpose: To address the behavioural, oxidative stress, and cytokine-mediated inflammatory pathways involved in sciatic nerve, current study protocol used Chronic Constriction Injury (CCI) Streptozotocin (STZ) induced methods. Materials Methods: Following CCI nerve administration of STZ 60mg/kg, rats develop painful neuropathy characterized by hyperalgesia, allodynia, neuroinflammation, increased total calcium levels. Results: Topiramate (20, 40, 80 mg/kg) treatment for two weeks beginning on 15th day surgery ending 29th diabetes confirmation significantly dose dependently reduced development allodynia hyperalgesia. Furthermore, topiramate produced significant dose-dependent antioxidant anti-inflammatory effects restoring balance stress decreasing levels markers such as TNF-a, IL-1, IL-6, well homogenate. Conclusion: summarize, different doses produces analgesic, antioxidant, dependent manner, owing curiosity understand underlying producing mechanism its translation into signs symptoms neuropathy. Keywords: Topiramate, CCI, STZ, Oxidative Stress, Cytokines.